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mesylate

mesylate

1 9.2
A salt form of a drug used to make it more stable and easier to absorb
  • noun
  • /ˈmɛsɪˌleɪt/
  • Specialized
: mesilato
  • In pharmaceutical formulations, imatinib mesylate is often preferred for its solubility and stability.
  • imatinib mesylate
  • effects of mesylate
  • administered mesylate

Examples

  • The imatinib mesylate groups in our study demonstrated a 50% decrease in intimal thickening and showed histological decreases in SMC migration.

    Academic text (2012)
  • Therefore, we conclude that imatinib mesylate exhibits vasculoprotective properties during the early stages of arterial thrombosis.

    Academic text (2012)
  • The x2 test was used to evaluate statistical differences in morphometric data between the imatinib mesylate and control groups.

    Academic text (2012)
  • Statistical analysis of paired data (imatinib mesylate and control) was performed using the Wilcoxon signed rank test.

    Academic text (2012)
  • SMC inhibition is known to occur at imatinib mesylate concentrations of 0.5 M to 10 M.

    Academic text (2012)
  • Side effects, including nausea, vomiting, and cytopenia, may be overcome by the development of local forms of imatinib mesylate.

    Academic text (2012)
  • Following anastomosis, imatinib mesylate was administered for one, three, and seven days, and the regression of intimal hyperplasia was recorded.

    Academic text (2012)
  • In our study, 400 mg tablets of imatinib mesylate were dissolved in PBS and administered systemically.

    Academic text (2012)
  • In the present study, we showed that relatively low doses of imatinib mesylate (10 mg/kg twice per day) mitigate the deleterious side effects of the drug.

    Academic text (2012)
  • In the literature, imatinib mesylate therapy has been used by cardiovascular surgeons to reduce neointimal hyperplasia due to balloon-induced injuries.

    Academic text (2012)

Surface Forms

mesylate singular
mesylates plural

Morphology

mesylate = methanesulfonic acid (opaque) = mesyl + ate

Formed from the technical combining form 'mesyl' (methanesulfonyl) plus the chemical suffix '-ate'; this structure and meaning are specialized and not guessable by general learners.

Etymology

Mesylate comes from the chemical group mesyl, which is short for methanesulfonyl, and the ending -ate meaning 'a salt or ester'. So a mesylate is the salt or ester made from methanesulfonic acid, which is why medicines are sometimes given as a mesylate to change their stability or absorption.