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determinant

determinant

1 9.8
The part of an antigen that an antibody binds to
  • noun
  • /dɪˈtɜːrmɪnənt/
  • Specialized
translation icon : epítopo
  • A single point mutation in a determinant altered binding by the antibody.
  • blood group determinants

Examples

  • It's remarkable that the intrinsic blue color of water is due primarily to molecular vibrations and not to direct electron interactions, which are the primary determinants of color in almost all other substances.

    Academic text (2011)
  • Her research focuses on virus evolution, virulence acquisition, and the identification of virulence determinants.

    Academic text (2015)
  • So this would be the sort of specific expression of this determinant for the case of two particle.

  • As Table 6 shows, years of military service is a significant determinant of white veteran In(earnings), adding about 6 percent (p = .01) to earnings per year served.

    Academic text (2003)
  • The precise biological determinants of the spatial deficit in TS patients are not known; however, three categories of explanations have been advanced.

    Academic text (1990)
  • Clay-soil induced local immune suppression is suggested as an important determinant of endemic KS.

    Academic text (1994)
  • HLA typing in straight back syndrome indicates that it is inherited as an autosomal dominant condition and suggests that the antigenic determinants may be located on chromosome 6.

    Academic text (2007)
  • The antigen's binding site is a crucial determinant that influences how effectively the immune response is triggered.

  • Researchers identified a specific determinant on the pathogen that antibodies attach to during immune response.

  • Understanding the determinant region of the antigen can help in designing more effective vaccines.

Synonyms

epitope
vsdeterminant
  • Specialized
1 9.9

Part of a viral or bacterial protein that an antibody binds to

focuses on a specific surface region rather than any general part
antigenic determinant
vsdeterminant
  • Specialized
8.0

The small part of a germ or protein that an antibody sticks to

is the same meaning but shorter and omits the descriptive adjective

Compounds

antigenic determinant
  • Specialized
8.0

The small part of a germ or protein that an antibody sticks to

Surface Forms

determinant singular
determinants plural

Morphology

determinant = determine (opaque) = determine + ant

Although formed by regular suffixation from 'determine', the immunological sense ('antigenic determinant') is a specialized meaning not inferable by an average B1 learner from 'determine'.

Etymology

Determinant comes from the Latin determinare meaning 'to set limits' or 'decide', made of de- and termin- ('end' or 'boundary'), the same root as determine. In biology a determinant is the small part of a molecule that 'decides' which antibody will bind, so the word fits because it marks the part that determines the immune response.