de novo
- adjective
- /deɪ ˈnoʊvoʊ/
- Specialized
:
de novo
- For hard selective sweeps, the initial frequency of the selected mutation was set to 0.00005, mimicking a single de novo mutation to the positively selected allele.
- de novo assembly
Examples
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Most of these variations are de novo, but some of them were assumed as being inherited in an autosomal-dominant manner.
Academic text (2018) -
We selected two genome-wide significant CDH13 SNPs for de novo genotyping in the replication study sample (n = 3,896).
Academic text (2015) -
Activated T cells are particularly dependent on this de novo synthesis.
Academic text (2007) -
So the idea, one idea is that autism risk genes are maintained in the population through de Novo mutations.
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Cervical lymphangioma is well recognized in pediatric practice but seldom presents de novo in adulthood.
Academic text (2010) -
De novo assemblies were performed by using SeqMan Pro NGen (DNAStar, Inc., Madison, WI, USA) with default parameters.
Academic text (2014) -
However, the de novo GR sites were preferentially located in the vicinity of RelA binding sites (median distance: 35 kb, Figure 4D).
Academic text (2017) -
De novo mutations can lead to various genetic disorders that aren't present in the parents.
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Researchers discovered that certain diseases arise from de novo genetic variations not inherited from either parent.
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Many cases of congenital conditions are attributed to de novo mutations occurring during early development.
Antonyms
Surface Forms
Morphology
de + novo
The sense ‘arising newly’ is directly compositional from Latin constituents de (of/from) + novo (new), so a learner who knows those morphemes can derive the meaning as ‘anew’ or ‘newly arisen’. This construction also parallels forms in Romance languages and scientific register usage, making the semantics transparent for learners familiar with the parts.
Etymology
De novo also comes from the Latin parts de 'from' and novo 'new', so it gives the image of a change that appears 'brand new' in a person. That's why a de novo mutation is one that appears in the child and was not inherited from the parents.
