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cytotoxicity

cytotoxicity

1 9.2
How much a drug or material harms living cells
  • noun
  • /ˌsaɪtəʊtɒkˈsɪsɪti/
  • Specialized
: citosotoxicidad
  • A low level of cytotoxicity in this compound makes it a safer alternative for use in treatments.
  • cell cytotoxicity

Examples

  • In a few studies on CML experimental models, miR-30a enhanced imatinib-induced cytotoxicity and promoted intrinsic apoptosis of CML cells.

    Academic text (2016)
  • Therefore, measuring cytotoxicity is very valuable for identifying compounds that may cause certain health risks in vivo.

    Academic text (2018)
  • Modified natural polymers have attracted much attention because of their better biocompatibility and lower cytotoxicity compared with synthesized polymers.

    Academic text (2018)
  • The sMUA AuPAMAM constructs showed the highest stability, gene transfection efficacy, and a reasonable cytotoxicity profile.

    Academic text (2018)
  • Glutathione, along with other antioxidants, protected the isolated outer hair cells against this cytotoxicity, suggesting a free radical mechanism for aminoglycoside toxicity.

    Academic text (1998)
  • In cytotoxicity experiments, T cells lysed hepatocytes that expressed HBcAg, and this cytotoxicity could be blocked by antibody to HBcAg or by HLA class I molecules.

    Academic text (1994)
  • Measuring cytotoxicity helps researchers understand how certain drugs impact living cells.

  • The study focused on the cytotoxicity of various chemicals to determine their effects on cancer cells.

Synonyms

toxicity
vscytotoxicity
  • Specialized
38 7.2

How poisonous a substance is to people or animals

refers specifically to harm directed at living cells rather than whole organisms

Antonyms

1 5.9

A state of being not harmful to people or animals

How Toxic

cytotoxicity
  • Specialized
1 9.2
toxicity
  • Specialized
38 7.2
nontoxicity
1 5.9

Surface Forms

cytotoxicity singular

Morphology

cytotoxicity = cytotoxic (semi-transparent) = cyto + toxic + ity

The suffix '-ity' clearly forms a noun from the adjective 'cytotoxic', but 'cyto-' is a specialized combining form (cell-) that may be unfamiliar to general learners.

Etymology

Cytotoxicity combines cyto- meaning 'cell' and toxic meaning 'poison', like in the word toxin. So cytotoxicity is the 'poison' effect on living cells, and it tells us how harmful something is to cells.