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Glite Dictionary
👩 A family name 🧬 A cell protein
Beclin

Beclin

9.9
A protein that helps cells remove and reuse damaged parts
  • proper noun
  • Specialized
translation icon : Beclin
  • Researchers have found that Beclin 1 is crucial for the cell's recycling process during autophagy.
  • Beclin 1
  • Beclin 1 cleavage
  • Beclin 1 and caspase

Examples

  • Previously, we found that overexpressing Beclin 1 in a model of AD reduced disease-associated amyloid plaques.

    Academic text (2018)

  • Previous reports have described a direct role for the multifunctional protein Beclin 1 in neurodegeneration 4-8.

    Academic text (2018)

  • Several studies have shown that RIPA-soluble Beclin 1 levels are decreased in the brains of human AD patients 5, 8.

    Academic text (2018)

  • Cumulatively, these findings suggest a role for Beclin 1 beyond autophagy.

    Academic text (2018)

  • We demonstrate that Beclin 1 is cleaved in brain lysates of human AD patients.

    Academic text (2018)

  • Importantly, the FL-beclin and N-beclin conditions did not differ from the control group.

    Academic text (2018)

  • In line with this, we previously did not observe a decrease in Beclin 1 levels in hAPP transgenic mice 5.

    Academic text (2018)

  • We therefore decided to treat neuronal cell lines expressing different Beclin 1 isoforms with Staurosporine.

    Academic text (2018)

  • Decreased Beclin 1 levels and altered distribution have further been reported in polyglutamine diseases, including Huntington's disease.

    Academic text (2018)

  • We believe a second mechanism may generate a potentially pro-apoptotic C-terminal Beclin 1 fragment that results from Beclin 1 cleavage.

    Academic text (2018)

Surface Forms

Beclin main

Etymology

Beclin names a protein that helps cells 'clean' and recycle damaged parts. A helpful way to remember it is that Beclin sounds like 'be clean', which fits its job of keeping the cell tidy.